产品中心

当前位置:首页>产品中心 >一抗 >单克隆抗体

Anti-Human IgD Rabbit Monoclonal Antibody, Clone#RM123

Primary Antibodies, Monoclonal Antibodies, Rabbit Monoclonal Antibodies, IHC ICC IF Antibodies

分类:

一抗 - 单克隆抗体

说明书:

M05183-1

3720元/100ug  

Human

ELISA, IHC

Monoclonal

3-4周

选择规格:

总价格:

---元*1

选择数量:

- +

Product Brief

  • 产品概况

    产品名称 Anti-Human IgD Rabbit Monoclonal Antibody, Clone#RM123
    产品描述 Anti-Human IgD Rabbit Monoclonal Antibody, Clone#RM123 tested in ICC, IHC, FC, ELISA, reactive to Human
    文献引用格式 Anti-Human IgD Rabbit Monoclonal Antibody, Clone#RM123 (Boster Biological Technology, Wuhan, China. Catalog #M05183-1)
    应用范围 ELISA, IHC
    抗体来源 Rabbit
    免疫原 Human IgD
    抗体规格 100ug

    产品详情

    克隆 Monoclonal
    克隆号 RM123
    内容 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
    *可以提供无载体抗体。
    浓度 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
    储存条件 -20°C

    指标相关信息 (来源: Uniprot.org)

    小贴士:你可以利用tissue specificity信息来帮助设计阳性和阴性对照。对此有疑问请联系我们技术服务部门。
    基因名 IGHD
    基因全名 Immunoglobulin heavy constant delta
    蛋白功能 Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD (PubMed:8774350, PubMed:10702483, PubMed:11282392). .
    Uniprot ID IGHD: P01880

    产品图片

    点击图片放大

Instructions

暂无介绍

Related products

暂无相关产品