Anti-EGFR Antibody 抗体

¥580.00¥980.00

SKU: PB0039 分类: ,
PB0039-western-blotting-result-390433
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产品货号: PB0039
规格价格: 0.1ml/580元; 0.2ml/980元
检验物种: human;rat
应用: WB
克隆: Polyclonal

产品描述

技术细节
试剂盒内容
指标信息
应用数据和图片
文献和用户反馈
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产品概况

产品名称 Anti-EGFR Antibody 抗体
产品描述 多克隆抗人、大鼠的Anti-EGFR Antibody 抗体可用于WB免疫印迹
文献引用格式 Anti-EGFR Antibody 抗体 (Boster Biological Technology, Wuhan, China. Catalog #PB0039)
应用范围 WB免疫印迹
抗体来源
免疫原 重组蛋白(来源于大肠杆菌)
抗体规格 0.1ml/580元;0.2ml/980元

产品详情

克隆 多克隆
产品形态 液体
内容 200μg/ml亲和纯化抗体,0.01M PBS,30%甘油。
*可以提供无载体抗体。
储存条件 连续使用时4°C存储,保质期六个月;长期存储时建议分装为10ul以上小包装-20°C存储,并避免反复冻融,保质期一年。

指标相关信息 (来源: Uniprot.org)

小贴士:你可以利用tissue specificity信息来帮助设计阳性和阴性对照。对此有疑问请联系我们技术服务部门。

基因名 EGFR
基因全名 Epidermal growth factor receptor
蛋白功能 Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. .
Tissue Specificity Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.
Sequence Similarities Epidermal growth factor receptor;2.7.10.1;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1;EGFR;ERBB, ERBB1, HER1;
Uniprot ID EGFR: P00533

指标背景简介

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

产品图片

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EGFR(PB0039)(MW:134KD,200KD)Hela,A549,A431细胞裂解,免疫印迹分析。

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